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WASHINGTON (Reuters) -
A Canadian study involving mice
shows that anti-impotence pills might protect the hearts of
people with a common form of muscular dystrophy, researchers
said on Monday.

Canadian researchers gave sildenafil, the active ingredient
in drug maker Pfizer Inc's Viagra, to mice with an animal
version of Duchenne muscular dystrophy, and found that it
improved their heart performance.

They said it would be premature to give Viagra to people
with the disease, but said the results indicate the drug
potentially could be used to prevent or delay heart failure in
children with Duchenne muscular dystrophy.

The mice were given doses of the drug comparable to those
administered to treat erectile dysfunction in men. The study,
published in the Alternative tadalafil
of the National Academy of
Sciences, showed that sildenafil cut the levels of damage to
contracting heart muscle cells.

“If you don't give the sildenafil, the heart of these mice
doesn't function as well as normal mice, and they are more
susceptible to stress-induced cell death,” said researcher
Christine Des Rosiers of the Montreal Heart Institute.

She said in an interview the drug worked to improve heart
performance in the mice by preventing the breakdown of a
naturally occurring chemical. Called cyclic guanosine
monophosphate, or cGMP, it is involved in a number of cellular
signaling pathways, the researchers said.

Other impotence drugs also affect the chemical cGMP,
including vardenafil, sold by Schering Plough under the brand
name Levitra, and tadalafil, sold by Eli Lilly and Co. under
the brand name Cialis.

Duchenne muscular dystrophy is an inherited wasting disease
erectile dysfunction causes
by weakness and progressive numero cas tadalafil
of the
muscles, including the heart muscle. It begins in the legs and
pelvis, and later affects the whole body. Most people with the
disease must use a wheelchair by about age 12.

It is caused by a genetic mutation of dystrophin, a protein
vital to muscle cells.

Heart problems can appear at around age 10 and they
progress quickly, affecting most people with the disease by age
20. These heart problems are an important cause of death among
patients with muscular dystrophy.

Sildenafil was developed as a heart drug and is widely
prescribed for erectile dysfunction as well as pulmonary
hypertension. The researchers said cialis tadalafil generic rezeptfrei
are under way
about possible future studies using the drug in patients with
muscular dystrophy.

“There's a lot of information on this drug that shows it
appears to be relatively safe in adults,” Des Rosiers said,
while emphasizing that future human clinical trials are needed
before doctors prescribe it for heart trouble in these
patients. (Editing by Maggie Fox and Doina Chiacu)

LOS ANGELES - Many of the pills marketed as safe herbal alternatives to Viagra and other prescription sex medications pose a hidden danger: For men on common heart and cialis generic tadalafil drugs, popping one could lead to a stroke, or even death.

“All-natural” products with names like Stamina-RX and Vigor-25 promise an apothecary’s delight of rare Asian ingredients, but many work because they contain unregulated versions of the very pharmaceuticals they are supposed to replace.

That dirty secret represents a special danger for the millions of men who take nitrates &151; rising to nearly $400 million last year. And dangerous knockoffs abound.

At greatest risk are the estimated 5.5 million American men who take nitrates &151; some with doses more than twice that of prescription erectile dysfunction medicine. Other testers report similar results, particularly among pills that promise immediate results.

While no deaths have been reported, the AP found records of emergency room visits attributed to all-natural sex pills in Georgia, Chicago, Philadelphia, San Diego and elsewhere.

An elderly man in a retirement community north of Los Angeles took an in-the-mail sample and landed in the hospital for four days. A Michigan man sued the maker of Spontane-ES, blaming it for the stroke he suffered 20 minutes after taking a freebie that was advertised as “extremely safe.” Tim Fulmer, a lawyer representing Spontane-ES, said the pill did not contain any pharmaceutical and was not responsible for the stroke.

Mark B. Mycyk, a Chicago emergency room doctor who directs Northwestern University’s clinical toxicology research program, said he is seeing increasing numbers of patients who unwittingly took prescription-strength doses of the alternatives, a trend he attributes to ease of purchase on the Internet and the desperation of vulnerable men. He said he wouldn’t be surprised if there’d been undetected deaths from bad herbal pills.

Some herbal labels warn off users with heart or blood-pressure problems if they have taken their medicine within six hours; some doctors say 24 hours or more would be safer.

The AP often couldn’t determine from records whether incidents reported to tracking systems of the federal Food and Drug Administration and state poison control centers involved mixing herbal alternatives with nitrates.

Some men in their 30s who went to emergency rooms after taking herbal sex pills were presumably otherwise healthy, but they showed the transitory side effects of the active ingredients in regulated impotency pharmaceuticals, such as difficulty seeing clearly or severe headaches, records show.

While public health officials don’t know the extent of the problem, they agree that incidents are vastly buy cialis where, with national tracking systems capturing perhaps as little as 1 percent of them. Victims may be embarrassed, and doctors rarely ask about supplements.

Since 2001, sales of supplements marketed as natural sexual enhancers have risen $100 million, to $398 million last year, including herbal mixtures, according to estimates by Nutrition Business Journal. Some legitimate herbal mixtures claim to work gradually over weeks; it’s the herbals marketed for immediate trysts that often are the problem.

Tight budgets, weak regulations and other priorities limit the FDA’s ability to police the products, often promoted via blasts of e-mail spam and fly-by-night Web sites.

“The Internet poses many enforcement challenges,” said Dr. Linda Silvers, who leads an FDA team that targets fraudulent health products sold online. “A Web site can look drug dysfunction erectile new and legitimate, but actually be an illegal operation.”

In many cases, the ingredients used to alter herbal pills come from Asia, particularly China, where the sexual enhancers are cooked up in labs at the beginning of a winding supply chain. The FDA has placed pills by two manufacturers in China and one from Malaysia on an import watch list.

Pills like Cialis generally retail at pharmacies for between $13 and $20, while herbals can cost less than $1, up to about $5.

Many health insurance plans provide limited coverage for prescription sex pills, especially for those with health-related difficulties. Few over-the-counter treatments are covered, and herbals aren’t likely to be among them, in part because they’re classified as foods not pharmaceuticals, said Mohit M. Ghose, spokesman for America’s Health Insurance Plans, which represents major health insurers.

Spiked pills have turned up in Thailand, Taiwan, Canada, Australia, New Zealand, Hong Kong, Malaysia, the United Kingdom and the United States, according to testing done by Pfizer Inc., the New York-based pharmaceutical giant that developed Viagra. The company said that 69 percent of 3,400 supplements it purchased in China contained sildenafil citrate, the main ingredient in Viagra. Pfizer didn’t check for the patented ingredients of its rivals.

Under U.S. law, because such pills are “dietary supplements,” they’re far less regulated than pharmaceuticals and face few barriers to market. Viagra, by contrast, underwent years of testing before it was publicly available.

While herbal alternatives often contain exact copies of the patented drugs, some makers tweak the molecules to keep the effect of the original pharmaceutical while avoiding the scrutiny of the FDA and outside testing labs.

Federal officials have only recently stepped up cialis generic online and prosecutions, and in any case, the FDA’s recall power is limited. Last week, in response to safety concerns about imported toothpaste, dog food and toys, President Bush recommended that the FDA be authorized to order mandatory recalls of dangerous products.

Currently, recalls are voluntary, and even if the agency determines that a product poses a “significant health risk,” a firm may refuse to cooperate. Plus, recalled products are widely offered on the Internet and pills are hard to round up.

Before a product called Nasutra was recalled a year ago by its manufacturer, the FDA had received a 30-year-old man’s report of a raging headache and an erection that wouldn’t go down. Following the recall, a 32-year-old man reported having spontaneous nose bleeds after taking the pill, records show.

E-mails requesting comment from Nasutra LLC, the company that voluntarily recalled the product in September 2006, were not returned. The FDA says the firm is located in Los Angeles; there is no listed phone number in the region.

During the past year, the FDA has orchestrated eight recalls of “herbal” pills that contained the ingredients found in Viagra, Cialis or Levitra, or their unregulated chemical cousins. Many of the firms were based around Los Angeles, their offices ranging from an unsigned door in a grungy hall on the fringe of downtown to a gated complex near Beverly Hills.

One recall involved a pill called Liviro3.

The current owner of the drug’s marketing and distributing firm said that after he tried the product, he quit his job at a car dealership and bought the brand name and stock of several thousand pills in 2004 for $450,000. In January, he said, FDA agents seized his stockpile after an agency lab found that Liviro3 contained tadalafil, the main ingredient in Cialis. The man told the AP he’d had no idea the pills were drug-laced.

One prosecution involved V. Vigor Corp., the Long Island-based maker of Vigor-25. While the product was advertised as containing Asian ginseng, lycium fruit and Chinese yam rhizome, FDA testing indicated that the pills contained Viagra.

Company executive Michael Peng had agreed to stop selling Vigor-25 following an FDA agent’s visit in late 2004, according to an arrest warrant affidavit. But between then and his arrest in September, at least 4.5 million pills were packaged for distribution, the affidavit said. According to prosecutors, Peng thought he could evade tests simply by switching from the sildenafil citrate he imported from China to Levitra’s active ingredient, vardenafil &151; in this instance, claiming that a pharmaceutical is a dietary supplement.

Two other pills, Spontane-ES and Stamina-RX, were made by companies run by Jared Wheat, who’s facing federal charges in Atlanta that he peddled knockoff pharmaceuticals cooked in a Central American lab. Prosecutors tried to keep Wheat from posting bail by asserting that he contemplated killing an FDA investigator and bribing a prosecutor.

Fulmer rejected those assertions, which did not lead to charges, saying Wheat is hardworking and nonviolent. Fulmer said Wheat’s two businesses are legitimate and continue to be successful.

Wheat was granted bond after pledging approximately $7.5 million in cash and property; he’s free under home confinement.

___

Associated Press researcher Julie Reed in New York and Associated Press writer Andrew Bridges in Washington contributed to this report.

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NEW YORK (Reuters Health) -
A tadalafil vardenafil sales revatio drug for erectile
dysfunction is safe and effective for men with spinal cord
injuries who have difficulty achieving erections, a new study
shows.

A total of 186 men were randomly assigned to receive
treatment with Cialis or placebo for 12 weeks. The study was
completed by 129 in the treatment group and by 34 in the
placebo group. The subjects, who were an average of 38 years
old, had uso prolungato tadalafil erectile dysfunction for six months or
longer. They were instructed to take the drug when they planned
to have sex.

Nearly 85 percent of men given Cialis (know generically as
tadalafil) said the drug improved their erections compared
with19.5 percent of men given placebo. Another 78.5 percent
said it improved their ability to engage in sexual activity
versus just 14.6 percent of those on placebo. Specifically, the
men on the active drug reported tadalafil citrate more successful
penetration and intercourse attempts. The most common side
effects were headache and urinary tract infection.

“On-demand treatment with tadalafil…may help improve the
sex lives of patients with erectile dysfunction and spinal cord
injury and their partners,” Dr. Francois Giuliano of Raymond
Poincare Hospital, Garches, France and colleagues conclude in
the study, published in the Archives of Neurology.

Just one in four men with a spinal cord injury can achieve
erections adequate for intercourse on their own, the
researchers point out. Cialis, which like Levitra and Viagra
belongs to the class of drugs known as oral phosphodiesterase 5
inhibitors that are the first-line treatment for erectile
dysfunction, has shown promise in treating the condition in men
with spinal cord injury.

Tadalafil is effective for a longer period of time than
Viagra and Levitra, and unlike the shorter-acting drugs, it
does not interact with fatty foods, Giuliano and colleagues
note.

This may offer men with spinal cord injury and their
partners a “more natural sexual experience,” they add. “Hence,
tadalafil may be the agent of choice for spinal cord injury
patients who do not want to plan their sexual activity around
medication dosing,” the researchers conclude.

SOURCE: Archives of Neurology, November 2007.

Read more on Cialis effective for men with spinal cord injury
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